Objective of the study. Assessment of the quality of life of patients with Wolff–Parkinson–White syndrome using the questionnaire "Quality of life of a patient with arrhythmia" depending on the operation, determination of relapse-free survival of patients more than 15 years follow-up period. Material and methods. The article presents a comprehensive analysis of the quality of life of patients using a specific questionnaire "Life of a patient with arrhythmia". We studied 191 patients with Wolff– Parkinson–White syndrome after surgical treatment for a follow-up period of more than 15 years. The quality of life parameters were analyzed depending on the method of surgical treatment. The patients were divided into three groups: group 1 – Sealy–Iwa operation, group 2 – electroimpuls destruction (fulguration), and group 3 – radiofrequency ablation. Results. The temporal aspect of the manifestation of relapses in the form of Kaplan–Meier relapse-free survival graphs is presented. The values of relapse-free survival in different types of surgery corresponded to this trend: the average duration of relapse in Sealy–Iwa was the greatest, being 22.55 ± 2.12 years (95%, confidence interval – 18.4–26.7), in electroimpulse destruction it was 17.01 ± 3.0 years (95%, confidence interval – 11.14–22.89), with radiofrequency ablation, the shortest period of relapse was observed, which was 6.65 ± 0.86 years (95%, сonfidence interval – 4.98–8.33). According to the analysis of the quality of life, no correlation was found between the average assessment of the quality of life and the operation (p = 0.954), as well as the development of rhythm disturbances (p = 0.214). It is revealed that the older the patient, the lower the quality of life indicators (p = 0.001). Conclusion. Currently, there are no reliable data in the medical literature on the long-term results (over 15 years of follow-up) of surgical treatment of patients with Wolff–Parkinson–White syndrome. The most informative in the study of the long-term results of surgical treatment of Wolff–Parkinson–White syndrome is the study of the timing of the development of relapses, as well as their impact on the quality of life of patients. Our comprehensive analysis of relapse-free survival allowed us to establish a shorter period of relapse in patients after radiofrequency ablation (6.65 ± 0.86 years).