The catheter ablation of ventricular tachycardia in non-ischemic cardiomyopathy is one of the most challenging procedures in electrophysiology. In this case report, we outline our current approach to ventricular tachycardia ablation in this population. We approach each procedure first with a thorough preliminary analysis of a superficial 12-lead electrocardiogram on spontaneous arrhythmias with the goal of non-invasive characterization of the underlying arrhythmogenic substrate. During the procedure itself, it is critical to distinguish the substrate in as much detail as possible from the endocardium using detailed electroanatomical mapping, as scar in non-ischemic cardiomyopathy may be patchy and frequently involves the mid-myocardium and/or epicardium. In this case, the criteria pointed to the endocardial location of the substrate, which determined the initial approach for mapping and ablation. Here we were able to eliminate recurrent arrhythmias from the endocardium, although we use the epicardial approach in a significant proportion of patients.