Objective – to evaluate the short and long-term results of isolated thoracoscopic resection of the left atrial appendage and the cost-effectiveness of the method. Material and methods. The study included 12 patients in whom the restoration of the sinus rhythm was considered as impractical. The refusal was due to a collective decision because of the presence of concomitant diseases or contraindications to thoracoscopic ablation of the left atrium. As a result, the patients underwent an isolated thoracoscopic resection of the left atrial appendage. Results. No perioperative complications were registered in our study. In the postoperative period, for 25 (8; 1) months, thromboembolic complications did not develop in any of the operated patients. Conclusion. Thoracoscopic resection of the left atrial appendage is an effective method of preventing thromboembolic complications in patients for whom restoration of the sinus rhythm is impractical. Thoracoscopic resection of the left atrial appendage can be a reliable alternative to the endovascular technique and is a less expensive method in comparison with the implantation of an occlusive device in the left atrial appendage.