Objective: investigation and analysis of the contribution of comorbid pathology, medical and social factors and medical awareness to the development of infectious complications in patients with cardiac implantable electronic devices (CIEDs) within a 5-year follow-up. Material and methods. Included were 1378 patients who had been implanted with CIEDs from January 2012 to December 2017. In the course of observation, 26 (1,9%) participants dropped out. The primary composite endpoint (PCEP) included infective endocarditis (IE) (valvular and/or electrode) with and without CIEDs generator pocket infection, CIEDs generator pocket infection with and without bacteremia, and cases of latent bacteremia with probable CIEDs infection. The Charlson comorbidity Index (IC) was calculated for all patients. The medical and social factors influencing the formation of infectious complications were studied. The analysis of the subjective assessment of patients with CIEDs of their health, the degree of attention to it, as well as various aspects of activities for the formation of a healthy lifestyle. Results. During 5 years of follow-up, 33 (2.5%) patients achieved PCEP. A comparative analysis of groups of patients without infection and patients who have achieved PCEP was carried out. A significant probability of CIEDs infection was associated with the values of Charlson's IC ≥ 4 points (odds ratio (OR) 2.25, p=0.036). Survival analysis (by Cox regression method) confirmed the association of a higher score on the Charlson scale with a higher incidence of infectious complications in patients with CIEDs (hazard ratio 2.22, p=0.023). An intergroup analysis of medical and social factors showed that belonging to a group with a low level of medical activity and a low level of medical awareness affects the likelihood of developing a CIEDs infection (OR 2.63, p=0.013 and OR 3.19, p=0.001, respectively). Patients with Charleson IC ≥ 4 points with low levels of medical activity and medical awareness had a worse prognosis (log-rank test p=0.027 and p=0.024, respectively). Conclusion. The burden of comorbidity is an important factor in the development of CIEDs infection. The revealed features of medical and preventive activity, especially in patients with a high burden of comorbidity, require improving medical literacy and managing risk factors that adversely affect health and are associated with an increase in the burden of comorbidity. This determines the need for a differentiated approach to the process of medical and informational impact on a patient with CIEDs.