Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by uncoordinated electrical activity of the atria and, as a result, their ineffective contraction. It is the most common cardiac arrhythmia associated with increased mortality and significant morbidity burden. The pulmonary veins, being the foci of ectopic extrasystoles in 84–94% of cases, play a leading role in the pathophysiology of AF. The arrhythmogenicity of the pulmonary veins themselves is explained by the presence of atrial myocardium in their tunica media – these striated muscles contain pacemaker and Purkinje cells similar to those found in the conduction system of the heart. Therefore, pulmonary vein isolation via radiofrequency catheter ablation remains the cornerstone in the treatment of drug-resistant AF. The purpose of this report is to demonstrate a clinical case of successful treatment of atrial fibrillation in a patient with a combination of the right and left trunk pulmonary veins. This patient experienced constantly recurrent paroxysms of atrial fibrillation, despite adequate antiarrhythmic therapy. The patient underwent surgery using advanced non-fluoroscopic mapping systems. The result of the operation was the successful isolation of both trunks of the pulmonary veins and the relief of tachycardia in the patient without electrical pulse therapy during the operation.