Atrial fibrillation is one of the most common atrial arrhythmias associated with a high risk of thromboembolic complications and leading to significant morbidity and mortality. The left atrial appendage is the source of more than 90% of cardiac thromboembolisms and strokes, and therefore is considered as a key link in the primary prevention of stroke in patients with atrial fibrillation. The growing popularity of surgical epicardial ablation and hybrid methods of endoepicardial ablation, especially in patients with more common forms of the disease, has increased interest in surgical methods for isolating the left atrial appendage. Minimally invasive treatment methods in modern cardiac surgery provide a unique opportunity to effectively isolate the left atrial appendage using various devices. It is important to understand the advantages and disadvantages of existing methods when deciding what to offer patients and in which cases one approach may be preferable to the other. Ongoing scientific research on methods and devices for isolating the left atrial appendage is a priority area of modern surgical and interventional arrhythmology. The article presents a comparative analysis of modern methods and devices for surgical isolation of the left atrial appendage, taking into account morphological, electrophysiological and surgical aspects, including a comparative assessment of the inflammatory response to implantation of various devices for isolation by clipping in a chronic experimental setting.